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The Oxygen Destroyer was a fictional weapon that appeared in Godzilla (1954 film). It was an extremely powerful weapon that was actually able to completely dissolve Godzilla and wipe out all life in the Tokyo Bay. It was also the only weapon that was truly effective against the monster.

Unintentionally created by Daisuke Serizawa during his experiments, the Oxygen Destroyer dissolved oxygen in water which instantly reduced any and all organic life within range to its skeletal frame. While it's never explained in either of the Godzilla films how removing oxygen causes such a destructive reaction, since the laws regarding the conservation of mass state that matter and energy can't be destroyed only converted into another form, it's possible that the Oxygen Destroyer actually converts oxygen into an entirely different element with highly corrosive properties. In the film, Serizawa was hesitant to use his device for fear of the damage it would cause but ultimately relented when he realized Godzilla was the greater threat.

In Godzilla vs. Destoroyah (1995), it turns out that the Oxygen Destroyer awakened and mutated Precambrian life forms that lived in Tokyo Bay that would merge together to form the stongest Kaiju ever recorded (taking Godzilla at the peak of his power, Godzilla Junior and Super X combined to finally destroy him) Destoroyah.

Stock footage from the first Godzilla film was also used in Godzilla Against Mechagodzilla (2002) and Godzilla: Tokyo S.O.S..

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