Crossovers that take places using characters from different comic book publishing companies.
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- Sonic & Mega Man: Worlds Collide
- Spawn/Batman
- Spawn/WildC.A.T.S.
- Spider-Man and Batman: Disordered Minds
- Spike (IDW Publishing)
- Star Trek/Green Lantern
- Star Trek/Planet of the Apes: The Primate Directive
- Star Trek/X-Men
- Star Trek: The Next Generation/Doctor Who: Assimilation2
- Superman/Aliens
- Superman and Batman versus Aliens and Predator
- Superman & Bugs Bunny
- Superman and Spider-Man
- Superman vs. Predator
- Superman vs. The Amazing Spider-Man
- Superman vs. The Terminator: Death to the Future
- Superman/Tarzan: Sons of the Jungle