Supervillains who hail from an alien race (i.e. a race that did not originate on Earth).
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- Majin Buu
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- Mars People
- Marvin the Martian
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- Darth Maul
- Maxima (DC Comics)
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- Megatron (Transformers)
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- Metarex
- Miles "Tails" Prower (Archie character)
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- Mother Brain (Metroid)
- Mister Mxyzptlk
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- Scarface (Predator)
- Shadow Galactica
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- Shredder (Teenage Mutant Ninja Turtles)
- Siege
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- Sinestro
- Sinestro Corps
- Sir Grodus
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- Smithy (Super Mario)
- Supreme Leader Snoke
- Jacen Solo
- Space Pirate (Metroid)
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- Starro
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- Super Buu
- Super-Skrull
- Superboy-Prime
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